NanoScaler

The NanoScaler contains five different Impingement Jets Mixers ( allowing researchers to determine the optimum encapsulation conditions before scaling up the process to run on a larger IJM NanoProducer unit.

Each system contains three pumps. The API solution is transferred via a loop to be mixed with the organic phase to minimise the sample volume. Finally, the LNP mixture is quenched in a second mixer.

You can still use the API pump directly without the loop for larger volumes.

The IJM NanoScaler is made with research and development and lab-scale production in mind.

Equipped with our proven Impingement Jets Mixing (IJM) technology for the production of lipid nanoparticles the NanoScaler allows researchers to determine the optimum encapsulation conditions for their mRNA based therapy before scaling up the process to run on a larger GMP-compliant IJM NanoProducer unit.

The NanoScaler is made for low sample consumption so as not to waste valuable API. Its small footprint means it can comfortably sit on the benchtop of a research and development lab. The system comes with five different KNAUER Impingement Jets Mixers to help researchers determine which conditions result in the optimum level of nucleotide encapsulation. In addition researchers can use their own custom mixing unit and benefit from the flexibility of the system set-up.

The encapsulation process can be remotely controlled by software; ran from a conventional PC or laptop, or even a tablet.

Available Upgrade-Kits

With our preconfigured Upgrade-Kits you can upgrade your IJM NanoScaler very easily and build up the system you need.

• A71103 Lipid Loop: Additional injection valve for lipids
• A71114 3x Flowmeter: Flowrate monitoring of all pumps