Greener solvents for GPC/SEC and light scattering of polymers

A crucial method in examining macromolecules like polymers and proteins is gel permeation chromatography (GPC), also known as size exclusion chromatography (SEC). This is a method that allows for the characterization of polymers and biomaterials to assess many properties like size and molecular weight. Choosing the right solvent for GPC/SEC is essential to obtaining reliable findings. Due to the hydrophobic nature of many polymers, the use of non-polar, organic solvents as a mobile phase is necessary. However, many of these solvents are derived from petrochemical sources and their disposal and usage can pose safety and environmental concerns.