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Tosoh Bioscience

TSKgel columns for Bio LC

TSKgel columns for Bio LC

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Description

 

TSKgel columns are designed for the analysis of proteins, peptides, biopolymers and low molecular weigth compounds by size exclusion, ion exchange, hydrohobic interaction, reversed phase, affinity and normal phase chromatography. The packings in the columns are either silica-based or polymer-based material in particle ranging from 2µm to 20 µm.

TSK-G or TSKgel

  • TSKgel UP-SW3000 columns packed with 2µm silica based particles are the latest addition to the popular TSK gel SW series, the gold standard for QC analysis of antibody therapeutics. The new silica-based UHPLC columns are based on the proven proprietary surface technology of the renowned TSKgel SW series and facilitate the transfer of existing HPLC methods to UHPLC systems.

  • HIGHLIGHTS:

    • Proven TSKgel SW SEC quality
    • Virtual absence of nonspecific interaction
    • Easy transfer of existing HPLC methods

    • Optimized for mAb quality control
      The new columns can be used with modern HPLC and UHPLC systems and are available with 15 or 30 cm length. The short one enables short analysis times; the long one provides higher resolution for mAb analysis. The lifetime of the columns can be improved when using the corresponding guard columns.

      • Size Exclusion Chromatography:
        Proteins (Biolpolymers)
        High Temperature GPC Columns
        Organic-soluble polymers
        Water-soluble polymers
        Polar-organic soluble polymers
      • Reversed Phase Chromatography:
      • Silica-based columns:  High purity Type B Silica, High efficiencies, Excellent recoveries, Low bleed for MS

New! TSKgel ODS-100V & 100Z, TSKgel ODS-140HTP for high throughput applications

New! TSKgel C4-300 Protein columns

Specialty columns ODS120-A, 120-T and Oligo DNA-RP

Methacrylate based columns: Hydrophilic backbone to improve recovery and reduce secondary interactions, Stable from pH 2.0 to 12.0, Compatible with organic solvents

    • Hydrophilic Interaction Chromatography - HILIC: TSKgel Amide-80, TSKgel NH2-100 (New!)
    • Size Exclusion Chromatography:
      Proteins (Biolpolymers)
      High Temperature GPC Columns
      Organic-soluble polymers
      Water-soluble polymers
      Polar-organic soluble polymers
    • Ion Exchange Chromatography:
      Anion Exchange
      Cation Echange
    • Hydrophobic Interaction  Chromatography - HIC
    • Afinity Chromatography
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TSKgel columns for Bio LC
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TSKgel columns for Bio LC brochure

TSK-Gel® SW kolommen voor gelfiltratie

TSKgel® SW size exclusion columns are widely used for aqueous analysis and isolation of proteins, antibodies, enzymes, nucleic acids and other biological macromolecules.

  • Columns show high resolution and sensitivity and have excellent solvent stability with up to 100% polar organic solvents
  • The smaller particle size of the UltraSW and SWXL materials result in reduced analysis times
  • UP-SW columns are now available for UHPLC-SEC applications improving productivity and resolution
  • All SW-type columns are available in stainless steel hardware; SWXL columns are also available in PEEK hardware
  • TSKgel® SuperSW mAb HR is the ideal scouting column for unknown molecular weight compounds

TSKgel® UP-SW:

With modern advances in technology, Tosoh Bioscience have launched a range of 2 µm UHPLC columns for use in SEC. The TSKgel® UP-SW3000 columns are available in 150 and 300 mm lengths for use on modern, low dead volume HPLC or UHPLC instrumentation. They provide short analysis times and allow analysts to achieve improved resolution compared with the equivalent larger particle size columns. Offering the same exclusion range as the TSKgel® G3000SWXL columns, these columns are ideal for fast separations of monoclonal antibody analysis or can be used to improve your separation.

TSKgel® UltraSW:

Launched in 2013, TSKgel® UltraSW columns contain spherical 3 µm particles (300 Å pore size). TSKgel® UltraSW Aggregate has a slightly larger pore size than the TSKgel® SuperSW mAb columns and provides a wider separation window for higher order monoclonal antibody aggregates.

TSKgel® SuperSW:

In 1997, Tosoh Bioscience launched the initial TSKgel® SuperSW columns which contain spherical 4 µm particles in 4,6×300 mm dimensions and extended this portfolio in 2013 with further columns including the SuperSW mAb HTP suitable for UHPLC applications. This range offers high sensitivity even with limited sample mass. The TSKgel® SuperSW mAb HR - 'HR' indicating high resolution - delivers superior resolution over the whole molecular weight range, from fragments to aggregates, when analysing monoclonals. It has the same column dimensions and molecular weight range as the well-established TSKgel® G3000SWXL.

TSKgel® SWXL:

Introduced in 1987, the TSKgel® SWXL column line were the second generation TSKgel® phases developed with 5 or 8 µm particle size packings. The smaller particle sizes of the TSKgel® SWXL columns mean these can be implemented to improve sample resolution or to reduce analysis time (over SW columns). The G3000SWXL has proven to be the industry standard for QC analysis of monoclonal antibodies. Columns feature high pore volume per unit column volume, low sample adsorption and high column efficiency, all contributing to excellent sample resolution.

TSKgel® SW:

The TSKgel® SW column line, introduced in 1977, were the first of a long line of high-performance Gel Filtration (GFC) columns that have become synonymous with analysing protein molecular weights. It features 10 or 13 µm particle sizes with improved sample capacity for protein isolation due to the large pore sizes.

Informatie over toebehoren: Corresponding guard columns are avaliable to protect the analytical columns. Direct connection, no holders are required.